Speakers

Sarah Le Merdy

Merck KGaA

Customer Application Consultant, ADC, EMEA

Sarah Le Merdy is Senior Customer Application Consultant, ADC, at Merck KGaA, Darmstadt, Germany. She brings over 20 years of expertise in biologics purification, closed processing, and ADC manufacturing, and is author of publications in BioPharm International on related topics. Sarah holds a Diploma of Engineering in Biochemistry and focuses on translating purification and single use system solutions into robust manufacturing workflows. She supports ADC manufacturers across Europe in implementing fit for purpose technologies that safeguard process safety and product quality while delivering on business objectives.

Leveraging single-use technologies for ADC manufacturing

Single-use technologies have been extensively used in the production of therapeutic drugs, particularly biologics, for decades, with their adoption continuing to expand. However, challenges related to plastic components have historically limited their application in antibody-drug conjugate (ADC) manufacturing. Recent advancements in these technologies now enable greater flexibility and transformation in ADC production.

This presentation will explore the potential of single-use technologies in ADC manufacturing, highlighting critical factors such as material selection, operating modes, and compliance with ADC-specific safety and quality criteria. Key data, design considerations, operational advantages, and practical applications of single-use in ADC production will also be discussed.

Merck KGaA

Research. Development. Production.

Merck is a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

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